Just another Reality-based bubble in the foam of the multiverse.

Friday, November 04, 2005

This Could Change Everything

I wonder who will get it first? And will they live in Texas, or Kennebunkport, or in a secret undisclosed location?

It blocks oxidative stress, among other things...

A defect in klotho gene expression in mice leads to a syndrome closely resembling human aging, including shortened life span, infertility, growth arrest, hypoactivity, skin atrophy, premature thymic involution, arteriosclerosis, osteoporosis, and pulmonary emphysema (1). Conversely, overexpression of the klotho gene extends the life span in the mouse (2), indicating that the klotho gene functions as an aging suppressor gene in mammals that delays aging when overexpressed and accelerates the development of aging-like disorders when disrupted...

It's a membrane-bound glycoprotein, except when the extracellular portion is cleaved, to act on other cells. Then it blocks aging.

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